"Mechanism of action of urocanase. Specific 13C-labelling of the
prosthetic
NAD+ and revision of the structure of its adduct with imidazole
propionate"
Klepp, J., Fallert-Müller, A., Grimm, K. and Rétey, J., Eur.J.Biochem.192,
669-676 (1990).
"Radical Intermediates in the Coenzyme B12 Dependent
Methylmalonyl-CoA
Mutase Reaction Shown by ESR Spectroscopy"
Zhao, Y., Such, P. und Rétey, J., Angew. Chem. Int. Ed. Engl.31,
215-216 (1992).
"Isolation, Sequencing and Expression in E. coli of the urocanase
gene
from white clover (Trifolium repens)"
Koberstaedt, A., Lenz, M. and Rétey, J., FEBS-Lett., 311,
No. 3, 206-208 (1992).
"Cloning, expression and analysis of the urocanase gene (hut U)
from
Pseudomonas putida"
Lenz, M. and Rétey, J., Eur.J.Biochem. 217,
429-434
(1993).
"Identification of Serine 143 as the most likely precursor of
dehydroalanine
in the active site of histidine ammonia-lyase. A study of the
overexpressed
enzyme by site-directed mutagenesis"
Langer, M., Reck, G., Reed, J. and Rétey J., Biochemistry 33,
6462-6467 (1994).
"On the Mechanism of the Urocanase Reaction: Confirmation of the
Structure
of the NAD+-Inhibitor Adduct by Direct 13C-13C Coupling"
Schubert, C., Zhao, Y., Shin J.-H. und Rétey, J., Angew.
Chem. Int. Ed. Engl. 33, 1279-1280 (1994).
"Serine-202 is the putative precursor of the active site
dehydroalanine
of phenylalanine ammonia-lyase. Site-directed mutagenesis studies on
the
enzyme from parsley (Petroselinum crispum L.)"
Schuster, B. and Rétey, J., FEBS-Lett. 349,
252-254
(1994).
"The Urocanase Story: A Novel Role of NAD+ as Electrophile"
Rétey, J., Arch. Biochem. Biophys. 314, 1-16
(1994).
"Electron Paramagnetic Resonance Studies of the Methylmalonyl-CoA
Mutase
Reaction. Evidence for Radical Intermediates Using Natural and
Artificial
Substrates as well as the Competitive Inhibitor 3-Carboxypropyl-CoA"
Zhao, Y., Abend, A., Kunz, M., Such, P. and Rétey, J., Eur.
J. Biochem. 225, 891-896 (1994).
"Histidine Ammonia-Lyase Mutant S143C is Posttranslationally
Converted
into Fully Active Wild-Type Enzyme"
Langer, M., Lieber, A. and Rétey, J., Biochemistry 33,
14034-14039 (1994).
"On the Mechanism of Action of Urocanase: Observation of the
Enzyme-Bound
NAD+-Inhibitor Adduct by 13C-NMR Spectroscopy"
Schubert, C., Röttele, H., Spraul,M. and Rétey, J., Angew.
Chem. Ed. Int. Engl. 34, 652-654 (1995).
"The Role of Dehydroalanine in the Catalysis by Histidine
Ammonia-Lyase"
Langer, M., Pauling, A. and Rétey, J., Angew. Chem. Ed. Int.
Engl. 34, 1464-1465 (1995).
"The mechanism of action of phenylalanine ammonia-lyase: the role
of
prosthetic dehydroalanine"
Schuster, B. and Rétey, J., Proc. Natl. Acad. Sci. USA 92,
8433-8437 (1995).
"Peripher substituierte Cobaloxime - die Struktur von delta-Hexyl
bis[1,8-di-(N-morpholino)octan-4,5-dioximato]pyridin
cobalt(III)" Köhler,B., Knauer, M., Clegg, W.,
Elsegood, M.R.J., Golding, B. und Rétey, J., Angew. Chem.107,
2580-2581 (1995); Angew. Chem. Int. Ed. Engl. 34,
2389-2390
(1995)
"On the Nature of the Irreversible Inhibition of Histidine Ammonia
Lyase
by Cysteine and Dioxygen"
Weber, K. and Rétey, J., Bioorg. & Med. Chem., 4,
1001-1006 (1996)
"Enzymatic Catalysis Using Friedel-Crafts-Type Reactions"
Rétey, J., Naturwissenschaften 83, 439-447
(1996)
"Synthesis and Reactions of a Chemical Model of the Urocanase
Reaction"
Winter, J. and Rétey, J., Chem. Eur. J. 3,
410-416
(1997)
"Kinetic Investigations using Inhibitors Mimicking the
Posthomolysis
Intermidiate in the Coenzyme B12 Dependent Glycerol Dehydratase and
Diol
Dehydratase Reactions"
Poppe, L. and Rétey, J., Eur. J. Biochem. 245,
398-401 (1997)
"Synthesis of nonhydrolyzable Acyl-Coenzyme A Analougoues"
Abend, A. and Rétey, J., Methods Enzymol. 279,
224-239 (1997)
"Identification of Essential Amino Acids in Phenylalanine
Ammonia-Lyase
by site-directed Mutagenesis"
Langer, B., Röther, D. and Rétey, J., Biochemistry 36,
10867-10871 (1997)
"Further insights into the mechanism of action of
methylmalonyl-CoA
mutase by electron paramagnetic resonance studies"
Abend, A. Illich, V. and Rétey, J., Eur. J. Biochem. 249,
180-186 (1997)
"A new base-off analogue of coenzyme B12 with a modified
nucleotide
loop: 1H-NMR structure analysis and kinetic studies with
(R)-methylmalonyl-CoA
mutase, glycerol dehydratase and dioldehydratase"
Poppe, L., Stupperich, E., Hull, W.E., Buckel, T. and Rétey,
J., Eur. J. Biochem. 250, 303-307 (1997)
"Dioldehydratase bindet das Coenzym B12 in der "Base-on" Form.
Elektronenspinresonanz-
Untersuchung mit [15N]Dimethylbenzimidazol"
Abend, A., Nitsche, R., Stupperich, E. and Rétey, J., Angew.
Chem. 110, 643-645 (1998) pdf
, Angew. Chem. Int. Ed. Engl. 37, 625-627 (1998)
"Synthesis and in vitro Evaluation of Ras-Farnesyltransferase
Inhibitor
Pepticinnamin E"
Hinterding, K., Hagenbuch, P., Rétey, J. and Waldmann, H., Angew.
Chem. 110, 1298-1301 (1998) pdf
, Angew. Chem. Int. Ed. Engl. 37, 1236-1238 (1998)
"Coenzyme B12-dependent enzymes and their models "in Vitamin B12
and
B12-Proteins"
Rétey, J., Proceedings of the 4. European Symposium on Vitamin
B12, Innsbruck, 1996 (Kräutler, B., Golding, B. ed.) Wiley-VCH
p.231.246
(1998)
"The Behavior of Substrate Analogues and Secondary Deuterium
Isotope
Effects in the Phenylalanine Ammonia-lyase Reaction"
Gloge, A., Langer, B., Poppe, L. and Rétey, J., Arch.
Biochem.
Biophys. 359, 1-7 (1998)
"The role and source of 5’- deoxyadenosyl radical in a carbon
skeleton
rearrangement catalyzed by a plant enzyme"
Ollagnier, S., Kervio, E. and Rétey, J., FEBS-Lett. 437,
309-312 (1998) pdf
"Synthesis and in vitro Evaluation of the
Farnesyltransferase
Inhibitor Pepticinnamin E."
Hinterding, K., Hagenbuch, P., Rétey, J. and Waldmann, H. Chem.
Eur. J. 5, 227-236 (1999)
"Mechanistic aspects of molybdenum-containing enzymes"
Hille, R., Rétey, J., Bartlewski-Hof, U. Reichenbecher, W. and
Schink, B. FEMS Microbiol. Rev. 22,
489-501
(1999) pdf
"A structural comparison of molybdenum cofactor-containing
enzymes"
Kisker, C., Schindelin, H., Baas, D., Rétey, J., Meckenstock,
R.U. and Kroneck, P.M.H. FEMS Microbiol. Rev. 22,
503-521
(1999) pdf
"Homogenization and crystallisation of histidine ammonia-lyase by
exchange
of a surface cysteine residue"
Schwede, T., Bädeker, M., Langer, M., Rétey, J. and Schulz,
G. E. Protein Engineering 12, 151-153 (1999)
"Binding of Cob(II)alamin to the Adenosylcobalamin-Dependent
Ribonucleotide
Reductase from Lactobacillus Leichmannii: Identification of
Dimethylbenzimidazole
as the Axial Ligand"
Lawrence, C.C., Gerfen G.J., Samano, V., Nitsche, R., Robins, M.J.,
Rétey, J. and Stubbe J., J. Biol. Chem. 274,
7039-7042 (1999)
"Crystal Structure of Histidine Ammonia-Lyase Revealing a Novel
Polypeptide
Modification as the Catalytic Electrophile"
Schwede, T., Rétey, J. and Schulz, G.E., Biochemistry 38,
5355-5361 (1999)
"Stereospecificity of the Coenzyme B12-Catalyzed
Rearrangements
and the Role of Negative Catalysis"
Rétey,J., (1999), Chemistry and Biochemistry of B12
(Banerjee,
R. ed.) John Wiley & Sons, N.Y. p. 271-287.
"Hydroxyalkylcobalamins as Competitive Inhibitors in Coenzyme B12
dependent
Enzymic Reactions: 1H-NMR Structure Analysis and Kinetic Studies with
Glycerol
Dehydratase and Dioldehydratase"
Poppe, L., Hull, W.E. , Nitsche, R., Graf, T., Stupperich, E. and
Rétey,
J. Helv. Chim. Acta 82, 1250-1265
(1999) pdf
"Ribonucleoside Triphosphate Reductase From Lactobacillus
Leichmannii:
Kinetic Evaluation of a Serie of Adenosylcobalamin Competitive
Inhibitors,
[v-(Adenosin-5´-o-yl)alkyl]cobalamins, which Mimic the Post
Co-C Homolysis Intermediate"
Suto, R.K., Poppe, L., Rétey, J. and Finke, G., Bioorg.
Chem. 27,
451-462 (1999).
"S-Adenosylmethionin-Armeleute-B12 ?"
Rétey., J. Chemie in unserer Zeit 33,
171-172
(1999)
"Cloning, Sequencing and Heterologous Expression of
Pyrogallol-Phloroglucinol
Transhydroxylase from Pelobacter adidigallici"
Baas, D. and Rétey, J., Eur. J. Biochem.265,
896-901(1999).
"Elucidation of the coenzyme binding mode of further B12-dependent
enzymes
using a base-off analogue of coenzyme B12"
Poppe, L., Bothe, H., Bröker, G., Buckel, W., Stupperich, E. and
Rétey, J., J. Mol. Catal. Enzym. 10, 345-350
(2000) pdf
"Ethanolamine Ammonia-Lyase has a "Base-on" binding mode for
Coenzyme
B12"
Abend, A., Bandarian, V., Nitsche, R., Stupperich, E., Rétey,
J. and Reed, G.H., Arch. Biochem. Biophys. 370, 138-141
(1999)
"Evidence for a 1,2 Shift of a Hydrogen Atom in a Radical
Intermediate
of the Methylmalonyl-CoA-Mutase Reaction"
Kunz, M. and Rétey, J. , Bioorg. Chem. 28,
134-139
(2000)
"Phenylalanine Ammonia- Lyase: The Use of Its Broad
Substrate
Specificity for Mechanistic Investigations and
Biocatalysis-Synthesis
of L-Arylalanine"
Gloge, A., Zon, J. Kövàri, A., Poppe, L. and Rétey,
J., Chem. Eur. J. 6, 3386-3390 (2000)
"Discovering New Enzymes and Metalbolic Pathways:
Conversion
of Succinate to Propionate by Escherichia coli"
Haller, T., Buckel, T., Rétey, J. and Gerlt, J., Biochemistry
39,
4622-4629 (2000)
"Further Insight into the Mechanism of the Irreversible
Inhibition
of Histidine Ammonia-Lyase by L-Cysteine and Dioxygen"
Merkel, D. and Rétey, J., Helv. Chim. Acta 83,
1151-1160 (2000) pdf
"Mimicking the Reaction of Phenylalanine-Ammonia-Lyase by a
Synthetic
Model"
Rettig, M., Sigrist, A. and Rétey, J., Helv. Chim. Acta 83,
2246-2265 (2000) pdf
"Methylidene-imidazol-one (MIO) from Histidine and Phenylalanine
Ammonia-Lyase
Langer, B., Langer, M. and Rétey, J. in Advances in
Protein
Chemistry Vol. 58 p. 175-214
Novel Cofactors Klinman, J. P. & Dove , I.E. eds. Academic Press.
(2000)
"Crossed Acyloin Condensation of Aliphatic Aldehydes"
Heck, R. Köhler, B. Golding, B.T. and Rétey, J., Eur.
J. Org. Chem. 2623-2627 (2001)
"The role of active site residues of histidine ammonia-lyase from
Pseudomonas
putida"
Röther, D., Schwede, T.F., Schulz, G.E. and Rétey, J. , Eur.
J. Biochem. 268, 6011-6019 (2001)
"1,4-Dihydro-L-alanine. Its Synthesis and Behaviour in the
Phenylalanine
Ammonia-Lyase Reaction"
Skolaut, A., Rétey, J. Archives Biochem. Biophys. 393,
187-191 (2001)
"Effect of Supramolecular Inclusion on the 1,2 Rearrangement of
Radicals"
Chen, Y., Kervio, E. and Rétey, J., Helv. Chim. Acta 85,
552-558 (2002)
"An active site homology model of phenylalanine ammonia-lyase from
Petroselinum
crispum"
Röther, D., Poppe, L., Morlock, G., Viergutz, S. and Rétey,
J., Eur. J. Biochem 269, 3065-3075 (2002)
"Use of Enzymes Inactivated by Site-Directed Mutagenesis for the
Preparation
of Enantioselective Membranes”
Skolaut, A. and Rétey, J.Angew. Chem. 114, 3094-3096
(2002); Angew. Chem. Int. Ed. 41, 2960-2962 (2002)
"Synthesis of Enantiomerically Pure Aristeromycylcobalamin and its
Behaviour
in the Dioldehydratase, Glyceroldehydratase, Ethanolamine Ammonia-Lyase
and Methylmalonyl-CoA Mutase Reactions"
Weigl, U., Heimberger, M., Pierik, A. and Rétey, J.Chem. Eur.
J. 9, 652-660 (2003)
"Discovery and Role of Methylidene Imidazolone, a Highly
Electrophilic
Prosthetic Group"
Rétey, J. , Biochim. Biophys. Acta 1647, 179-184 (2003)
"Properties and Synthetic Applications of Ammonia-Lyases"
Poppe, L. and Rétey, J. Curr. Org. Chem. 7 (13), 1297-1315 (2003)
"Mechanistic Investigations on Phenylalanine Ammonia-Lyase using
N-Methylated Phenylalanines"
Viergutz, S., Poppe, L., Tomin, A. and Rétey, J. , Helv. Chim.
Acta. 86, 3601-3612 (2003)
“Kinetic Analysis ot the Reactions Catalyzed by Histidine and
Phenylalanine Ammonia-Lyases”
Viergutz, S. and Rétey, J.Chem. & Biodiversity, 1, 296-302
(2004)
“Structure and Action of Urocanase”
Kessler, D., Rétey, J., Schulz, G.E., J. Mol. Biol. 342,
183-194 (2004)
“Mechanisms: the elucidation of fascinating new Enzyme-catalysed
reaction continues”
Rétey, J. and Liu, H. W., Curr. Opin. Chem. Biol. 8, 451-453
(2004)
“Friedel-Crafts type attack facilitates the enzymic ammonia
elimination from histidine and phenylalanine”
Poppe, L., and Rétey, J., Angew. Chem. 117, 3734-3754 (2005);
Angew. Chem. Int. Ed. 44, 3668-3688 (2005)