Selected Publications :

    "Enzymic Reaction Selectivity by Negative Catalysis or how do Enzymes deal with Highly Reactive Intermediates"
    Rétey, J., Angew. Chem. Int. Ed. Engl.  29, 355-361 (1990).

    "Mechanism of action of urocanase. Specific 13C-labelling of the prosthetic NAD+ and revision of the structure of its adduct with imidazole propionate"
    Klepp, J., Fallert-Müller, A., Grimm, K. and Rétey, J., Eur.J.Biochem.192, 669-676 (1990).

    "Radical Intermediates in the Coenzyme B12 Dependent Methylmalonyl-CoA Mutase Reaction Shown by ESR Spectroscopy"
    Zhao, Y., Such, P. und Rétey, J., Angew. Chem. Int. Ed. Engl.31, 215-216 (1992).

    "Isolation, Sequencing and Expression in E. coli of the urocanase gene from white clover (Trifolium repens)"
    Koberstaedt, A., Lenz, M. and Rétey, J., FEBS-Lett., 311, No. 3, 206-208 (1992).

    "Cloning, expression and analysis of the urocanase gene (hut U) from Pseudomonas putida"
    Lenz, M. and Rétey, J., Eur.J.Biochem. 217, 429-434 (1993).

    "Identification of Serine 143 as the most likely precursor of dehydroalanine in the active site of histidine ammonia-lyase. A study of the overexpressed enzyme by site-directed mutagenesis"
    Langer, M., Reck, G., Reed, J. and Rétey J., Biochemistry 33, 6462-6467 (1994).

    "On the Mechanism of the Urocanase Reaction: Confirmation of the Structure of the NAD+-Inhibitor Adduct by Direct 13C-13C Coupling"
    Schubert, C., Zhao, Y., Shin J.-H. und Rétey, J., Angew. Chem. Int. Ed. Engl. 33, 1279-1280 (1994).

    "Serine-202 is the putative precursor of the active site dehydroalanine of phenylalanine ammonia-lyase. Site-directed mutagenesis studies on the enzyme from parsley (Petroselinum crispum L.)"
    Schuster, B. and Rétey, J., FEBS-Lett. 349, 252-254 (1994).

    "The Urocanase Story: A Novel Role of NAD+ as Electrophile"
    Rétey, J., Arch. Biochem. Biophys. 314, 1-16 (1994).

    "Electron Paramagnetic Resonance Studies of the Methylmalonyl-CoA Mutase Reaction. Evidence for Radical Intermediates Using Natural and Artificial Substrates as well as the Competitive Inhibitor 3-Carboxypropyl-CoA"
    Zhao, Y., Abend, A., Kunz, M., Such, P. and Rétey, J., Eur. J. Biochem. 225, 891-896 (1994).

    "Histidine Ammonia-Lyase Mutant S143C is Posttranslationally Converted into Fully Active Wild-Type Enzyme"
    Langer, M., Lieber, A. and Rétey, J., Biochemistry 33, 14034-14039 (1994).

    "On the Mechanism of Action of Urocanase: Observation of the Enzyme-Bound NAD+-Inhibitor Adduct by 13C-NMR Spectroscopy"
    Schubert, C., Röttele, H., Spraul,M. and Rétey, J., Angew. Chem. Ed. Int. Engl. 34, 652-654 (1995).

    "The Role of Dehydroalanine in the Catalysis by Histidine Ammonia-Lyase"
    Langer, M., Pauling, A. and Rétey, J., Angew. Chem. Ed. Int. Engl. 34, 1464-1465 (1995).

    "The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine"
    Schuster, B. and Rétey, J., Proc. Natl. Acad. Sci. USA 92, 8433-8437 (1995).

    "Peripher substituierte Cobaloxime - die Struktur von delta-Hexyl bis[1,8-di-(N-morpholino)octan-4,5-dioximato]pyridin cobalt(III)" Köhler,B., Knauer, M., Clegg, W.,
    Elsegood, M.R.J., Golding, B. und Rétey, J., Angew. Chem.107, 2580-2581 (1995); Angew. Chem. Int. Ed. Engl. 34, 2389-2390 (1995)

    "On the Nature of the Irreversible Inhibition of Histidine Ammonia Lyase by Cysteine and Dioxygen"
    Weber, K. and Rétey, J., Bioorg. & Med. Chem., 4, 1001-1006 (1996)

    "Enzymatic Catalysis Using Friedel-Crafts-Type Reactions"
    Rétey, J., Naturwissenschaften 83, 439-447 (1996)

    "Synthesis and Reactions of a Chemical Model of the Urocanase Reaction"
    Winter, J. and Rétey, J., Chem. Eur. J. 3, 410-416 (1997)

    "Kinetic Investigations using Inhibitors Mimicking the Posthomolysis Intermidiate in the Coenzyme B12 Dependent Glycerol Dehydratase and Diol Dehydratase Reactions"
    Poppe, L. and Rétey, J., Eur. J. Biochem. 245, 398-401 (1997)

    "Synthesis of nonhydrolyzable Acyl-Coenzyme A Analougoues"
    Abend, A. and Rétey, J., Methods Enzymol. 279, 224-239 (1997)

    "Identification of Essential Amino Acids in Phenylalanine Ammonia-Lyase by site-directed Mutagenesis"
    Langer, B., Röther, D. and Rétey, J., Biochemistry 36, 10867-10871 (1997)

    "Further insights into the mechanism of action of methylmalonyl-CoA mutase by electron paramagnetic resonance studies"
    Abend, A. Illich, V. and Rétey, J., Eur. J. Biochem. 249, 180-186 (1997)

    "A new base-off analogue of coenzyme B12 with a modified nucleotide loop: 1H-NMR structure analysis and kinetic studies with (R)-methylmalonyl-CoA mutase, glycerol dehydratase and dioldehydratase"
    Poppe, L., Stupperich, E., Hull, W.E., Buckel, T. and Rétey, J., Eur. J. Biochem. 250, 303-307 (1997)

    "Dioldehydratase bindet das Coenzym B12 in der "Base-on" Form. Elektronenspinresonanz- Untersuchung mit [15N]Dimethylbenzimidazol"
    Abend, A., Nitsche, R., Stupperich, E. and Rétey, J., Angew. Chem. 110, 643-645 (1998) pdf , Angew. Chem. Int. Ed. Engl. 37, 625-627 (1998)

    "Synthesis and in vitro Evaluation of Ras-Farnesyltransferase Inhibitor Pepticinnamin E"
    Hinterding, K., Hagenbuch, P., Rétey, J. and Waldmann, H., Angew. Chem. 110, 1298-1301 (1998)  pdf , Angew. Chem. Int. Ed. Engl. 37, 1236-1238 (1998)

    "Coenzyme B12-dependent enzymes and their models "in Vitamin B12 and B12-Proteins"
    Rétey, J., Proceedings of the 4. European Symposium on Vitamin B12, Innsbruck, 1996 (Kräutler, B., Golding, B. ed.) Wiley-VCH p.231.246 (1998)

    "The Behavior of Substrate Analogues and Secondary Deuterium Isotope Effects in the Phenylalanine Ammonia-lyase Reaction"
    Gloge, A., Langer, B., Poppe, L. and Rétey, J., Arch. Biochem. Biophys. 359, 1-7 (1998)

    "The role and source of 5’- deoxyadenosyl radical in a carbon skeleton rearrangement catalyzed by a plant  enzyme"
    Ollagnier, S., Kervio, E. and Rétey, J., FEBS-Lett. 437, 309-312 (1998)          pdf

    "Synthesis and  in vitro  Evaluation of the Farnesyltransferase Inhibitor Pepticinnamin E."
    Hinterding, K., Hagenbuch, P., Rétey, J. and Waldmann, H. Chem. Eur. J. 5, 227-236 (1999)

    "Mechanistic aspects of molybdenum-containing enzymes"
    Hille, R., Rétey, J., Bartlewski-Hof, U. Reichenbecher, W. and Schink, B.   FEMS Microbiol. Rev.  22, 489-501 (1999)         pdf

    "A structural comparison of molybdenum cofactor-containing  enzymes"
    Kisker, C., Schindelin, H., Baas, D., Rétey, J., Meckenstock, R.U. and  Kroneck, P.M.H. FEMS Microbiol. Rev. 22, 503-521 (1999)        pdf

    "Homogenization and crystallisation of histidine ammonia-lyase by exchange  of a  surface cysteine residue"
    Schwede, T., Bädeker, M., Langer, M., Rétey, J. and Schulz, G. E.  Protein Engineering 12, 151-153 (1999)

    "Binding of Cob(II)alamin to the Adenosylcobalamin-Dependent Ribonucleotide Reductase from Lactobacillus Leichmannii: Identification of Dimethylbenzimidazole as the Axial Ligand"
    Lawrence, C.C., Gerfen G.J., Samano, V., Nitsche, R., Robins, M.J., Rétey, J. and Stubbe J.,  J. Biol. Chem. 274, 7039-7042 (1999)

    "Crystal Structure of Histidine Ammonia-Lyase Revealing a Novel Polypeptide Modification as the Catalytic Electrophile"
    Schwede, T.,  Rétey, J. and Schulz, G.E., Biochemistry 38, 5355-5361 (1999)

    "Stereospecificity of the Coenzyme B12-Catalyzed  Rearrangements and the Role of Negative Catalysis"
    Rétey,J., (1999), Chemistry and Biochemistry  of B12 (Banerjee, R. ed.) John Wiley & Sons, N.Y. p. 271-287.

    "Hydroxyalkylcobalamins as Competitive Inhibitors in Coenzyme B12 dependent  Enzymic Reactions: 1H-NMR Structure Analysis and Kinetic Studies with Glycerol Dehydratase and Dioldehydratase"
    Poppe, L., Hull, W.E. , Nitsche, R., Graf, T., Stupperich, E. and Rétey, J. Helv. Chim. Acta 82, 1250-1265 (1999)        pdf

    "Ribonucleoside Triphosphate  Reductase From Lactobacillus Leichmannii: Kinetic Evaluation of a Serie of Adenosylcobalamin Competitive Inhibitors, [v-(Adenosin-5´-o-yl)alkyl]cobalamins,  which Mimic the Post Co-C Homolysis Intermediate"
    Suto, R.K., Poppe, L., Rétey, J. and Finke, G., Bioorg. Chem. 27, 451-462 (1999).

    "S-Adenosylmethionin-Armeleute-B12 ?"
    Rétey., J.  Chemie in unserer Zeit 33, 171-172 (1999)

    "Cloning, Sequencing and Heterologous Expression of  Pyrogallol-Phloroglucinol Transhydroxylase from Pelobacter adidigallici"
    Baas, D. and Rétey, J.,  Eur. J.  Biochem.265, 896-901(1999).

    "Elucidation of the coenzyme binding mode of further B12-dependent enzymes  using a base-off analogue of coenzyme B12"
    Poppe, L., Bothe, H., Bröker, G., Buckel, W., Stupperich, E. and Rétey, J., J. Mol. Catal. Enzym. 10, 345-350 (2000)    pdf

    "Ethanolamine Ammonia-Lyase has a "Base-on" binding mode for Coenzyme B12"
    Abend, A., Bandarian, V., Nitsche, R., Stupperich, E., Rétey, J. and Reed, G.H., Arch. Biochem. Biophys. 370, 138-141 (1999)

    "Evidence for a 1,2 Shift of a Hydrogen Atom in a Radical Intermediate of the Methylmalonyl-CoA-Mutase Reaction"
    Kunz, M. and Rétey, J. , Bioorg. Chem. 28, 134-139 (2000)

     "Phenylalanine Ammonia- Lyase: The Use of Its Broad Substrate Specificity for Mechanistic Investigations  and Biocatalysis-Synthesis of L-Arylalanine"
    Gloge, A., Zon, J. Kövàri, A., Poppe, L. and Rétey, J., Chem. Eur. J. 6, 3386-3390 (2000)

     "Discovering New Enzymes and  Metalbolic Pathways: Conversion of Succinate to Propionate by Escherichia coli"
    Haller, T., Buckel, T., Rétey, J. and Gerlt, J., Biochemistry 39, 4622-4629 (2000)

    "Further Insight into the Mechanism of the Irreversible  Inhibition of Histidine Ammonia-Lyase by L-Cysteine and Dioxygen"
    Merkel, D. and Rétey, J.,  Helv. Chim. Acta 83, 1151-1160 (2000)         pdf

    "Mimicking the Reaction of Phenylalanine-Ammonia-Lyase by a Synthetic Model"
    Rettig, M., Sigrist, A. and Rétey, J., Helv. Chim. Acta 83,  2246-2265  (2000)        pdf

    "Methylidene-imidazol-one (MIO) from Histidine and Phenylalanine Ammonia-Lyase
    Langer, B., Langer, M. and Rétey, J.  in Advances in Protein Chemistry Vol. 58 p. 175-214
    Novel Cofactors Klinman, J. P. & Dove , I.E. eds. Academic Press. (2000)

    "Crossed Acyloin Condensation of Aliphatic Aldehydes"
    Heck, R. Köhler, B. Golding, B.T. and Rétey, J., Eur. J. Org. Chem. 2623-2627 (2001)

    "The role of active site residues of histidine ammonia-lyase from Pseudomonas putida"
    Röther, D., Schwede, T.F., Schulz, G.E. and Rétey, J. , Eur. J. Biochem. 268, 6011-6019 (2001)

    "1,4-Dihydro-L-alanine. Its Synthesis and Behaviour in the Phenylalanine Ammonia-Lyase Reaction"
    Skolaut, A., Rétey, J. Archives Biochem. Biophys. 393, 187-191 (2001)


    "Effect of Supramolecular Inclusion on the 1,2 Rearrangement of Radicals"
    Chen, Y., Kervio, E. and Rétey, J., Helv. Chim. Acta 85, 552-558 (2002)

    "An active site homology model of phenylalanine ammonia-lyase from Petroselinum crispum"
    Röther, D., Poppe, L., Morlock, G., Viergutz, S. and Rétey, J., Eur. J. Biochem 269, 3065-3075 (2002)

    "Use of Enzymes Inactivated by Site-Directed Mutagenesis for the Preparation of Enantioselective Membranes”
    Skolaut, A. and Rétey, J.Angew. Chem. 114, 3094-3096 (2002); Angew. Chem. Int. Ed. 41, 2960-2962 (2002)


    "Synthesis of Enantiomerically Pure Aristeromycylcobalamin and its Behaviour in the Dioldehydratase, Glyceroldehydratase, Ethanolamine Ammonia-Lyase and Methylmalonyl-CoA Mutase Reactions"
    Weigl, U., Heimberger, M., Pierik, A. and Rétey, J.Chem. Eur. J. 9, 652-660 (2003)

     "Discovery and Role of Methylidene Imidazolone, a Highly Electrophilic Prosthetic Group"
    Rétey, J. , Biochim. Biophys. Acta 1647, 179-184 (2003)

     "Properties and Synthetic Applications of Ammonia-Lyases"
    Poppe, L. and Rétey, J. Curr. Org. Chem. 7 (13), 1297-1315 (2003)

    "Mechanistic Investigations on Phenylalanine Ammonia-Lyase using N-Methylated Phenylalanines"
    Viergutz, S., Poppe, L., Tomin, A. and Rétey, J. , Helv. Chim. Acta. 86, 3601-3612 (2003)

     
    “Kinetic Analysis ot the Reactions Catalyzed by Histidine and Phenylalanine Ammonia-Lyases”
    Viergutz, S. and Rétey, J.Chem. & Biodiversity, 1, 296-302 (2004)

     “Structure and Action of Urocanase”
    Kessler, D., Rétey, J., Schulz, G.E.,  J. Mol. Biol. 342, 183-194 (2004)

    “Mechanisms: the elucidation of fascinating new Enzyme-catalysed reaction continues”
    Rétey, J. and Liu, H. W., Curr. Opin. Chem. Biol. 8, 451-453 (2004)

    “Friedel-Crafts type attack facilitates the enzymic ammonia elimination from histidine and phenylalanine”
    Poppe, L., and Rétey, J., Angew. Chem. 117, 3734-3754 (2005); Angew. Chem. Int. Ed. 44, 3668-3688 (2005)

    “Structural and functional comparison of HemN to other radical SAM enzymes”
    Layer, G., Kervio, E., Morlock, G., Heine, D. W., Jahn, D., Rétey, J. and Schubert, W.–D.Biol. Chem. 386, 971-980 (2005)

    "The Interaction of Heteroaryl-Acrylates and Alanines with Phenylalanine Ammonia-Lyase from Parsley”
    Paizs, Cs. Katona, A. and Rétey, J., Chem. Eur. J. 12, 2739-2744 (2006)

    “Chemoenzymatic One-Pot Synthesis of Enantiopure L-Arylalanines from Arylaldehydes”
    Paizs, Cs, Katona, A. and Rétey, J., Eur. J. Org. Chem. 1113-1116 (2006)

    “The Essential Tyr-containing Loop Conformation and the Role of the C-terminal Multihelix Region in Eukaryotic Phenylalanine Ammonia-Lyases”
    Pilbàk, S., Tomin, A., Rétey, J. and Poppe, L., FEBS J. 273, 1004-1019 (2006)

    “Inhibition of Histidine Ammonia-Lyase by Heteroaryl-Alanines and Acrylates”
    Katona, A. Tosa, M.I., Paizs, Cs. and Rétey, J., Chem. Biodiv. 3, 502-508 (2006)





     
     


    Last changes   08/2006